Therapeutic Intervention in Acute Ischemic Stroke: a Paradigm Shift
DOI:
https://doi.org/10.2015/hc.v6i4.428Keywords:
acute ischemic stroke, thrombolysis, reperfusion, recanalizationAbstract
Strokes are classified as ischemic or hemorrhagic. Acute ischemic strokes (AIS) are more common than hemorrhagic and they refer to thrombosis or embolism. They are classified into large artery infarctions, small vessel or lacunar infarctions and cardioembolic infarctions. As timely restoration of blood flow (reperfusion) using thrombolytic therapy or percutaneous intervention is the key and most effective strategy for salvaging ischemic myocardial tissue in acute myocardial infarction, the same principle applies to AIS. There is a narrow therapeutic window during which this can be accomplished, since the benefit of reperfusion continually decreases over time. During the acute phase of ischemia, be it myocardial or cerebral, a rapid determination and triaging of patients who are eligible for reperfusion is key to the success of such a salvaging strategy (... excerpt)
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).