The Role of Fluorodeoxyglucose Standardized Uptake Value in Diagnosis, Staging and Restaging of Non-Small Cell Lung Cancer

  • Maria Boudali EVAGELISMOS Hospital, Athens, Greece
  • Lina Skoura
  • Ioannis Datseris
  • Konstantinos Syrigos
Keywords: Fluorodeoxyglucose, positron emission tomography, lung cancer, standardized uptake value, non-small lung cancer


Molecular imaging with [18F]-fluorodeoxyglucose positron emission tomography / computed tomography ([18F]FDG-PET/CT) has become part of the standard of care in oncology patients. In oncology, the quantification for the analysis of PET data is an important tool for tumor diagnosis, staging, determination of prognosis and assessment of response to treatment. In clinical practice, standardized uptake value (SUV), a semi-quantitative parameter, is the most widely used parameter for the analysis of tracer uptake in PET imaging. The purpose of this review is to evaluate the role of the SUV in diagnosis, staging and restaging of the lung cancer, and also to establish the differences in [18F]FDG uptake across different histopathological subtypes of non-small lung cancer (NSCLC). Furthermore another purpose of the study is to gather and compare the SUVmax cut-off values, in differentiating benign from malignant lesions, in assessing the response to treatment and finally to identify the optimal threshold.