Adalimumab-Associated Isolated Splenic Tuberculosis In A Patient With Psoriasis Following A Negative Screening With Tuberculin Skin Test And QuantiFERON-Gold

Authors

  • Panayiotis Stavroulakis First Department of Internal Medicine Prefecture General Hospital 'Agios Georgios' Chania, Crete Greece
  • Afroditi Nikolidaki First Department of Internal Medicine Prefecture General Hospital 'Agios Georgios' Chania, Crete Greece
  • Stylianos Daskalogiannis Ultrasound Unit, Department of Radiology, Prefecture General Hospital 'Agios Georgios' Chania, Crete Greece
  • Kostantinos Kolokouris Computed Tomography Unit, Department of Radiology Prefecture General Hospital 'Agios Georgios' Chania, Crete Greece
  • Panagiotis Fanourgiakis First Department of Internal Medicine Prefecture General Hospital 'Agios Georgios' Chania, Crete Greece

DOI:

https://doi.org/10.2015/hc.v5i4.238

Abstract

We describe a rare form of extrapulmonary tuberculosis and, to our knowledge, the first reported case of isolated splenic tuberculosis in association with adalimumab treatment. In addition, our case demonstrates that the interpretation of a negative tuberculin skin test may prove problematic even in otherwise healthy individuals with no predisposing factors, especially in the face of biologic treatment. A history of BCG vaccination in adulthood may pose additional burdens in the evaluation of such patients facing the risks of anti-TNF agents. As to QuantiFERON, further investigation is warranted in order to be incorporated in the screening for latent tuberculosis infection.

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Published

2010-09-01

Issue

Vol. 5 No. 4 (2010)

Section

CASE REPORTS

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