Galectins 7 and 9 in Dermatology : Current knowledge and future perspectives
Keywords:epidermis, β-galactoside-binding proteins, galectin 7, galectin 9
Galectins constitute a family of β-galactoside-binding proteins lectins that are widely distributed in nature occurring in mammals, sponges, fungi, nematodes, insects and viruses. Galectins are involved in fundamental cellular processes in human skin and other tissues and exert biological effects of paramount importance through interactions with cytoplasmic and nuclear proteins and with components of cell surface and extracellular matrix, as well.
In this paper we summarize current knowledge on the expression of galectins 7 and 9 in normal and diseased human skin and present the future perspectives of the use of these galectins or their antagonists/inhibitors in the diagnosis, prognosis and treatment of cutaneous disorders.
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