Acute Kidney Injury in Patients with COVID – 19 Infection: Α Tertiary Referral Hospital Experience

Authors

  • Dr. Christina- Danai Skondra Department of Nephrology, Evagellismos General Hospital, Ipsilantou 45-47, 10676, Athens, Greece
  • Dimitra Kozikopoulou
  • Theodora Oikonomaki
  • Glikeria Tsouka
  • Myrto Giannopoulou
  • Eleni Magira
  • Elias Siempos
  • Stylianos Kokkoris
  • Spyridon Zakynthinos
  • Christalleni Christodoulidou

Abstract

The emersion of the new coronavirus SARS COV 2 (Severe Acute Respiratory Syndrome
Coronavirus 2) was rapidly characterized as a pandemic by WHO. The major
manifestation of the virus is respiratory distress; however, the involvement of other organs
should not be overlooked. The kidney is one of the most important target organs
of the specific virus with acute kidney injury (AKI) described in 5-36% of COVID
positive patients and an average 25% within the severely ill.
Purp ose: The purpose of this study was to consider the incidence of AKI in patients
with COVID 19 in our cohort and to better understand risk factors associated with
AKI. Further, we wanted to investigate the impact of AKI on survival and in hospital
mortality.
Methods: Patients admitted to Evagelismos General Hospital with confirmed COVID-
19 infection from 11th March until 22th May were investigated. Patients 18 years
old as well as transplanted patients were excluded from this study. AKI was defined
according to the AKI criteria.
Results : From 99 patients with COVID-19 infection, AKI occurred in 41 (41.4%).
A total of 44 patients (44.4%) were admitted to Intensive Care Unit (ICU) and 31 of
them (70.5%) developed AKI. Of the 44 patients with AKI, 16 (39%) required renal
replacement therapy. Hospital mortality, in total, was 16.2% (37% among patients
with AKI versus 0.02% among those without AKI, p=0.000).
Conclusion: AKI was common among patients hospitalized with COVID 19. AKI
was associated with older age, clinical severity and existing CKD.

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Published

2021-09-02